Program:
5:30 PM Social and Registration
6:15 PM Complimentary Dinner
6:55 PM Welcome and Opening Remarks
7:05 PM Speaker 1
8:00 PM Speaker 2
First Speaker: Xuanwen Shawn Li, Principal Scientist at Merck & Co
Title: Identification and Control of High-Risk Host Cell Proteins for Biopharmaceutical Process Development with Advanced LC-MS-Based Proteomic Approaches
Abstract: Host cell proteins (HCPs) are bioprocess impurities originating from the host cells used in biopharmaceutical manufacturing. Identifying and controlling high-risk HCPs is essential for maintaining product quality and shelf life. Notably, HCPs with hydrolase activity can degrade formulation excipient polysorbates, reducing drug stability. In this presentation, we will discuss advanced LC-MS-based proteomic approaches, including high-throughput proteomics and activity-based protein profiling (ABPP), to identify high-risk HCPs for biopharmaceutical process development and to enable product quality control.
Second Speaker: Matt Willetts, US Proteomics Applications Manager at Bruker Scientific, LLC
Title: New developments in Single Cell Proteomics and Immunopeptidomics on the timsTOF Ultra 2
Abstract: Recent advancements in the timsTOF Ultra 2 system have significantly impacted the fields of single-cell proteomics and immunopeptidomics. We will present new workflows for single cell analysis that enable more than 1000 single cells to be analyzed per day and new acquisition and data processing methods for immunopeptidomics. We will also present our new AIP technology which promises further improvements in peptide and protein IDs.
Sponsor:
Please register. It’s free, including dinner, but registration is required.